{"id":1306,"date":"2022-05-05T13:01:20","date_gmt":"2022-05-05T11:01:20","guid":{"rendered":"https:\/\/www.phitogen.it\/processo-produttivo\/"},"modified":"2023-11-23T18:06:55","modified_gmt":"2023-11-23T17:06:55","slug":"production-process","status":"publish","type":"page","link":"https:\/\/www.phitogen.it\/en\/production-process\/","title":{"rendered":"Production process"},"content":{"rendered":"[vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”50px” equal_height=”yes” content_placement=”middle” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#e3eaee” bg_image=”459″ bg_position=”center center” background_image_loading=”default” bg_repeat=”no-repeat” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][divider line_type=”No Line” custom_height=”160″ custom_height_phone=”60″ custom_height_tablet=”80″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”no-extra-padding” column_padding_phone=”no-extra-padding” column_padding_position=”right” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

Production process: sustainability, innovation and quality Made in Italy<\/span><\/strong><\/h1>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][divider line_type=”No Line” custom_height=”20″ custom_height_phone=”0″][vc_column_text]\n

Inspired by the biological changes in plant genetics, Phitogen Beauty Labs has devised cyclical maintenance protocols<\/strong> based on soft treatments to safeguard natural beauty.<\/h3>\n[\/vc_column_text][vc_column_text]To manufacture medical devices based on Hyaluronic Acid, the company uses raw materials of excellent quality and an eco<\/strong>–sustainable production process, with high technological innovation and completely Made in Italy.<\/strong>[\/vc_column_text][divider line_type=”No Line” custom_height=”50″ custom_height_phone=”0″][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin_tablet=”-100″ bottom_margin_phone=”-60″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][image_with_animation image_url=”1056″ image_size=”full” animation_type=”entrance” animation=”None” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”110%” max_width_mobile=”default”][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”90px” equal_height=”yes” content_placement=”middle” column_direction=”default” column_direction_tablet=”column_reverse” column_direction_phone=”column_reverse” bg_color=”#e4e9ee” scene_position=”center” top_padding=”180″ bottom_padding=”160″ top_padding_tablet=”120″ bottom_padding_tablet=”0″ top_padding_phone=”30″ bottom_padding_phone=”0″ text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” enable_gradient=”true” color_overlay=”#e4e9ee” color_overlay_2=”#ffffff” advanced_gradient_angle=”0″ overlay_strength=”1″ gradient_direction=”top_to_bottom” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin_phone=”-20″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][image_with_animation image_url=”1058″ image_size=”full” animation_type=”entrance” animation=”None” hover_animation=”none” alignment=”” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”110%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”0″ custom_height_tablet=”120″ custom_height_phone=”110″][\/vc_column][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” left_margin=”-120″ left_margin_phone=”0″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default” offset=”vc_hidden-sm vc_hidden-xs”][divider line_type=”No Line” custom_height=”40″ custom_height_tablet=”40″ custom_height_phone=”120″][vc_column_text]\n

Latest generation facilities<\/strong><\/span><\/h1>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default” offset=”vc_hidden-lg vc_hidden-md”][divider line_type=”No Line” custom_height=”40″ custom_height_tablet=”60″ custom_height_phone=”80″][vc_column_text]\n

Latest generation facilities<\/strong><\/span><\/h1>\n[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”padding-10-percent” column_padding_tablet=”no-extra-padding” column_padding_phone=”no-extra-padding” column_padding_position=”left” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

At its 8,000 square metre manufacturing site based in San Benedetto del Tronto in the Marche region of Italy, Phitogen Beauty Labs makes use of the most advanced manufacturing systems and techniques<\/strong> in the field of aesthetic and orthopaedic medicine.<\/h3>\n[\/vc_column_text][vc_column_text]The production cycle of Hyaluronic Acid-based medical devices<\/strong>, both intradermal and intra-articular, takes place in clean rooms<\/strong> under the supervision of highly qualified personnel.[\/vc_column_text][vc_column_text]From the selection and extraction of raw materials to packaging and storage, Phitogen medical devices are manufactured according to strict production protocols, in compliance with ISO 9001, ISO 13485 and ISO 14001 quality management system procedures.<\/strong>[\/vc_column_text][divider line_type=”No Line” custom_height=”0″ custom_height_tablet=”40″ custom_height_phone=”30″][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#e6e9ee” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”1″ gradient_direction=”top_to_bottom” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][divider line_type=”No Line” custom_height=”160″ custom_height_phone=”40″ custom_height_tablet=”100″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_column_text]\n

The way of beauty by Phitogen<\/strong><\/span><\/h1>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/6″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin_phone=”-40″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”2\/3″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][divider line_type=”No Line” custom_height=”0″ custom_height_phone=”0″ custom_height_tablet=”0″][vc_column_text]\n

The Phitogen manufacturing process consists of eight different stages that make up the \u201cpath to beauty\u201d. Each is performed in strict compliance with national and international regulations, applying the highest safety standards.<\/span><\/h3>\n[\/vc_column_text][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/6″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][\/vc_row_inner][divider line_type=”No Line” custom_height=”40″ custom_height_phone=”0″ custom_height_tablet=”0″][\/vc_column][\/vc_row][vc_row type=”full_width_content” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#f8f9fb” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” enable_gradient=”true” color_overlay=”#e6e9ee” color_overlay_2=”#f8f9fb” advanced_gradient_angle=”0″ overlay_strength=”1″ gradient_direction=”top_to_bottom” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default” offset=”vc_hidden-sm vc_hidden-xs”][image_with_animation image_url=”1428″ image_size=”full” animation_type=”entrance” animation=”None” hover_animation=”none” alignment=”center” border_radius=”none” box_shadow=”none” image_loading=”default” max_width=”100%” max_width_mobile=”default”][divider line_type=”No Line” custom_height=”30″ custom_height_phone=”50″ custom_height_tablet=”0″][\/vc_column][\/vc_row][vc_row type=”full_width_content” full_screen_row_position=”middle” column_margin=”default” equal_height=”yes” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_color=”#e3eaee” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”1″ 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1.<\/h4>\n

Raw materials<\/b><\/h3>\n

Ultra-pure hyaluronic acid<\/b>, which at this stage is still in powder state, is placed in special containers where it is weighed, sealed and taken to the sterile liquid filling department where the more viscous hyaluronic acid solution is prepared.<\/b>[\/nectar_hotspot][nectar_hotspot left=”28.2293%” top=”17.1679%” position=”top”]\n

2.<\/h4>\n

Cross-Linking<\/b><\/h3>\n

In this first stage, ultra-pure Hyaluronic Acid with no nucleic acids and no residual proteins is mixed with the cross-linking agent BDDE at low temperature over a long period of time. This unique manufacturing process, known as cross-linking, preserves the specific visco-elastic properties of Hyaluronic Acid<\/b>, and above all allows smaller quantities of the chemical cross-linking agent BDDE to be used, resulting in a superior quality product with a very high degree of biocompatibility<\/b>.[\/nectar_hotspot][nectar_hotspot left=”60.60893021120294%” top=”13.334479071188513%” position=”top”]\n

3.<\/h4>\n

Purification<\/b><\/h3>\n

The mixture is purified using a dialysis process via WFI (water for injection). This process eliminates any residual BDDE molecules<\/b>, ensuring a product with a high level of purity and low toxicity.[\/nectar_hotspot][nectar_hotspot left=”70.59228650137742%” top=”33.18247784906813%” position=”right”]\n

4.<\/h4>\n

Mixing<\/b><\/h3>\n

The product is mixed with a buffered solution to provide a neutral pH value.[\/nectar_hotspot][nectar_hotspot left=”50.043%” top=”48.4073%” position=”right”]\n

5.<\/h4>\n

Filling<\/b><\/h3>\n

The resulting mixture is placed in the tank of a filling machine with lack of oxygen, where it will remain for several hours while waiting for the lab tests to prove that it meets the quality and purity requirements.<\/b> Once checked, the product is ready to be filled using an automatic filling machine.[\/nectar_hotspot][nectar_hotspot left=”25.017217630853995%” top=”66.19691414604338%” position=”left”]\n

6.<\/h4>\n

Sterilisation<\/b><\/h3>\n

The pre-filled syringes are then autoclaved, using moist heat for 15 minutes at 121 degrees Celsius. Once the sterilisation process is complete, the syringes are left on stand-by while waiting for the results of the quality control tests.[\/nectar_hotspot][nectar_hotspot left=”34.42091368227732%” top=”85.96471127406049%” position=”left”]\n

7.<\/h4>\n

Quality control and product release<\/b><\/h3>\n

At this stage, final tests<\/b> are carried out to certify that the quality and safety requirements<\/b> for the release of the finished product have been met: – Extrudability and pH control – External tests at certified laboratories – Sterility and LAL test – and Visual inspection.[\/nectar_hotspot][nectar_hotspot left=”71.51056014692378%” top=”78.57661167124962%” position=”right”]\n

8.<\/h4>\n

Packaging<\/b><\/h3>\n

At this stage, the syringe is placed in a thermoformed blister pack sealed with medical paper and inserted into the packaging. Finally, the product is packed and transferred to the warehouse where it will be stored at storage temperatures while awaiting dispatch to the customer.[\/nectar_hotspot][\/nectar_image_with_hotspots][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][\/vc_row_inner][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” top_margin_tablet=”-120″ top_margin_phone=”0″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default” offset=”vc_hidden-lg vc_hidden-md vc_hidden-xs”][nectar_image_with_hotspots image=”1310″ preview=”https:\/\/www.phitogen.it\/wp-content\/uploads\/2022\/05\/PHITOGEN_Processo-produttivo-infografica_mobile_ENG.jpg” color_1=”Accent-Color” hotspot_icon=”numerical” tooltip=”hover” tooltip_shadow=”small_depth”][nectar_hotspot left=”33.6489898989899%” top=”40.17147876565842%” position=”left”]\n

1.<\/h4>\n

Raw materials<\/b><\/h3>\n

Ultra-pure hyaluronic acid<\/b>, which at this stage is still in powder state, is placed in special containers where it is weighed, sealed and taken to the sterile liquid filling department where the more viscous hyaluronic acid solution is prepared.<\/b>[\/nectar_hotspot][nectar_hotspot left=”29.14657943067034%” top=”17.653910785212343%” position=”top”]\n

2.<\/h4>\n

Cross-Linking<\/b><\/h3>\n

In this first stage, ultra-pure Hyaluronic Acid with no nucleic acids and no residual proteins is mixed with the cross-linking agent BDDE at low temperature over a long period of time. This unique manufacturing process, known as cross-linking, preserves the specific visco-elastic properties of Hyaluronic Acid<\/b>, and above all allows smaller quantities of the chemical cross-linking agent BDDE to be used, resulting in a superior quality product with a very high degree of biocompatibility<\/b>.[\/nectar_hotspot][nectar_hotspot left=”60.79258494031221%” top=”13.823327222731438%” position=”top”]\n

3.<\/h4>\n

Purification<\/b><\/h3>\n

The mixture is purified using a dialysis process via WFI (water for injection). This process eliminates any residual BDDE molecules<\/b>, ensuring a product with a high level of purity and low toxicity.[\/nectar_hotspot][nectar_hotspot left=”71.32690541781452%” top=”33.18056828597617%” position=”right”]\n

4.<\/h4>\n

Mixing<\/b><\/h3>\n

The product is mixed with a buffered solution to provide a neutral pH value.[\/nectar_hotspot][nectar_hotspot left=”51.1421028466483%” top=”49.01657500763825%” position=”right”]\n

5.<\/h4>\n

Filling<\/b><\/h3>\n

The resulting mixture is placed in the tank of a filling machine with lack of oxygen, where it will remain for several hours while waiting for the lab tests to prove that it meets the quality and purity requirements.<\/b> Once checked, the product is ready to be filled using an automatic filling machine.[\/nectar_hotspot][nectar_hotspot left=”26.302800734618913%” top=”67.0523984112435%” position=”left”]\n

6.<\/h4>\n

Sterilisation<\/b><\/h3>\n

The pre-filled syringes are then autoclaved, using moist heat for 15 minutes at 121 degrees Celsius. Once the sterilisation process is complete, the syringes are left on stand-by while waiting for the results of the quality control tests.[\/nectar_hotspot][nectar_hotspot left=”35.706496786042244%” top=”86.69798350137489%” position=”left”]\n

7.<\/h4>\n

Quality control and product release<\/b><\/h3>\n

At this stage, final tests<\/b> are carried out to certify that the quality and safety requirements<\/b> for the release of the finished product have been met: – Extrudability and pH control – External tests at certified laboratories – Sterility and LAL test – and Visual inspection.[\/nectar_hotspot][nectar_hotspot left=”71.32690541781452%” top=”79.06545982279255%” position=”right”]\n

8.<\/h4>\n

Packaging<\/b><\/h3>\n

At this stage, the syringe is placed in a thermoformed blister pack sealed with medical paper and inserted into the packaging. Finally, the product is packed and transferred to the warehouse where it will be stored at storage temperatures while awaiting dispatch to the customer.[\/nectar_hotspot][\/nectar_image_with_hotspots][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][\/vc_row_inner][divider line_type=”No Line” custom_height=”30″ custom_height_phone=”50″ custom_height_tablet=”0″][\/vc_column][\/vc_row][vc_row type=”full_width_background” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” bg_image=”958″ bg_position=”center center” background_image_loading=”default” bg_repeat=”no-repeat” scene_position=”center” bottom_padding_phone=”0″ text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” advanced_gradient_angle=”0″ overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none” shape_type=”” gradient_type=”default”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” bottom_margin_phone=”-30″ column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][divider line_type=”No Line” custom_height=”120″ custom_height_tablet=”60″ custom_height_phone=”40″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” centered_text=”true” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” advanced_gradient_angle=”0″ gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/2″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid” gradient_type=”default”][vc_column_text]\n

Are you looking for support to develop hyaluronic acid-based products?<\/strong><\/span><\/h2>\n[\/vc_column_text][divider line_type=”No Line” custom_height=”50″ custom_height_tablet=”30″ custom_height_phone=”30″][nectar_btn size=”jumbo” button_style=”regular” button_color_2=”Accent-Color” icon_family=”default_arrow” text=”CONTACT US” url=”\/en\/contacts\/”][\/vc_column_inner][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/4″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][\/vc_column_inner][\/vc_row_inner][divider line_type=”No Line” custom_height=”30″ custom_height_tablet=”30″ custom_height_phone=”30″][vc_row_inner column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” text_align=”left” row_position=”default” row_position_tablet=”inherit” row_position_phone=”inherit” overflow=”visible” pointer_events=”all”][vc_column_inner column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”][vc_raw_html]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[\/vc_raw_html][\/vc_column_inner][\/vc_row_inner][divider line_type=”No Line” custom_height=”180″ custom_height_tablet=”100″ custom_height_phone=”80″][\/vc_column][\/vc_row][vc_row type=”in_container” full_screen_row_position=”middle” column_margin=”default” column_direction=”default” column_direction_tablet=”default” column_direction_phone=”default” scene_position=”center” text_color=”dark” text_align=”left” row_border_radius=”none” row_border_radius_applies=”bg” overflow=”visible” overlay_strength=”0.3″ gradient_direction=”left_to_right” shape_divider_position=”bottom” bg_image_animation=”none”][vc_column column_padding=”no-extra-padding” column_padding_tablet=”inherit” column_padding_phone=”inherit” column_padding_position=”all” column_element_spacing=”default” background_color_opacity=”1″ background_hover_color_opacity=”1″ column_shadow=”none” column_border_radius=”none” column_link_target=”_self” column_position=”default” gradient_direction=”left_to_right” overlay_strength=”0.3″ width=”1\/1″ tablet_width_inherit=”default” tablet_text_alignment=”default” phone_text_alignment=”default” animation_type=”default” bg_image_animation=”none” border_type=”simple” column_border_width=”none” column_border_style=”solid”]
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Phitogen Beauty Labs<\/strong><\/h3>\n

The parent company of a group of companies that for over twenty years have focused on providing contract manufacturing and distribution of medical devices based on hyaluronic acid used in aesthetic medicine and dermocosmetics.<\/p>\n<\/div>\n\n\n\n

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<\/h3>\n

Contacts<\/strong><\/h3>\n

<\/h3>\n

<\/p>\n

Via Valtellina, 21
San Benedetto del Tronto (AP)
63074 - Italy<\/p>\n

Tel: +39 0735 762020<\/a>
Email: frontoffice@phitogen.it<\/a><\/p>\n<\/div>\n\n\n\n\n\t\t<\/div> \n\t<\/div>\n\t<\/div> \n<\/div><\/div>

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\n\t\t\t\t\n\t\t\t<\/div> \n\t\t<\/div>\n\t<\/div> \n<\/div><\/div><\/div>[\/vc_column][\/vc_row]\n","protected":false},"excerpt":{"rendered":"Production process: sustainability, innovation and quality Made in Italy Inspired by the biological changes in plant genetics, Phitogen Beauty Labs has devised cyclical maintenance protocols based on soft treatments to...","protected":false},"author":3,"featured_media":112,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"content-type":"","inline_featured_image":false,"footnotes":""},"class_list":["post-1306","page","type-page","status-publish","has-post-thumbnail"],"yoast_head":"\nProduction process - Phitogen Beauty Labs<\/title>\n<meta name=\"description\" content=\"To manufacture medical devices based on Hyaluronic Acid, the company uses raw materials of excellent quality and an eco\u2013sustainable production process, with high technological innovation and completely Made in Italy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.phitogen.it\/processo-produttivo\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Production process - 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